Neuronal activity in the glioma microenvironment
نویسندگان
چکیده
منابع مشابه
Buzz Kill: Neuronal Activity Promotes Glioma Proliferation.
demonstrated ability to cross the blood-brain barrier and to permeate the brainstem. Rapid advances in understanding DIPG biology and identifying new potential therapies have resulted from discovery of theDIPGH3.3 K27M mutation. New insights into the molecular mechanisms underlying DIPG tumorigenesis have revealed promising molecular therapeutic agents that alter histone methylation biology (su...
متن کاملExtracellular Matrix Microenvironment in Glioma Progression
Malignant gliomas are primary brain tumors, which are highly invasive but not known to metastasize outside the central nervous system (CNS). The median survival time of patients with glioma is only 6 months to 2 years depending on various patient, tumor and treatment parameters (Louis et al. 2007). The highly aggressive character of gliomas with glioblastoma multiforme (GBM) being the most aggr...
متن کاملTumor Microenvironment in Treatment of Glioma
Glioma is one of the most malignant and fatal tumors in adults. Researchers and physicians endeavor to improve clinical efficacy towards it but made little achievement. In recent years, people have made advances in understanding characteristics and functions of tumor microenvironment and its role in different processes of tumor. In this paper, we describe the effects of tumor microenvironment o...
متن کاملNeuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion
Active neurons exert a mitogenic effect on normal neural precursor and oligodendroglial precursor cells, the putative cellular origins of high-grade glioma (HGG). By using optogenetic control of cortical neuronal activity in a patient-derived pediatric glioblastoma xenograft model, we demonstrate that active neurons similarly promote HGG proliferation and growth in vivo. Conditioned medium from...
متن کاملWNT signaling in microglia and the glioma microenvironment
MicroRNAs (miRNAs) are short, 22–25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3’-untranslated region (3’-UTR) of coding mRNA targets, interrupting translation and inducing degradation of these targets. The long 3’-UTRs of brain transcripts compared to other tissues predict important roles for brain miRNAs. Supporting this notion, we found th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Neurobiology
سال: 2017
ISSN: 0959-4388
DOI: 10.1016/j.conb.2017.10.009